Shifting How the World Innovates

From our founding, we made the decision that we’d be different.

In the way we’re structured, in the people we hire, in our trials and technology—and in the way we research and innovate transformative solutions on the frontiers of oncology and autoimmune disease.

Shifting toward disease-centric therapies, we seek to treat patients holistically, allowing us to target diseases and their consequences on the human body on multiple levels.

Strategic priorities for biologics discovery research in immuno-oncology

  • Optimize molecular attributes of ISB 1342 (CD38 x CD3) T-cell engager
  • Deliver a competitive MM portfolio by advancing next wave of T-cell engagers and innate immune engagers (e.g., NK, macrophages)
  • Accelerate delivery of  innovative concepts by leveraging tri-specific T-cell and innate immune engagers (e.g., NK, macrophages)
  • Optimize molecular attributes of  ISB 1302 (HER2 x CD3) T-cell engager

Shifting our approach to treating cancer

The current cancer treatment landscape is carved from centuries of scientific knowledge, gained by those dedicated to advancing a greater understanding of the human body. Diagnoses once thought incurable have now shifted, with new thinking, new research, new therapies, and new discoveries made possible by those who walked the path of innovation before us.1

Now, it’s our turn. We’re pioneering advancements in oncology that enhance the immune system’s ability to detect and kill cancer. Born from our patented BEAT® (Bispecific Engagement by Antibodies based on the T-cell receptor) technology platform, our immuno-oncology assets currently in Phase 1 clinical trials facilitate binding of powerful immune cells called CD3 (or T cells) to HER2- and CD38-expressing tumors.2 This may allow for the treatment of cancers such as breast and multiple myeloma, including those non-responsive or resistant to standard care.

Together with our biologics discovery work, our strategy for the creation of small molecules that may address new targets and traditionally undruggable targets places us on a path to innovation that holds great promise for the future.*

We believe that we can find ways to treat cancer differently.

*Ichnos research on small molecules is conducted by Glenmark Pharmaceuticals Ltd. through a service agreement.

Shifting novel autoimmune disease treatments forward

At Ichnos Sciences, we’re working to change the therapeutic approaches of autoimmune diseases.

With a deep understanding of the body’s aberrant autoimmune response that leads to the immune system attacking healthy cells and causing inflammation, our molecule, ISB 830, is designed to block the key immune system activation factor, OX-40.3 By blocking OX-40 on the surface of T cells, ISB 830 down-regulates overactive T cells to “normalize” their activity and slow the immune system’s auto-reactive responses, reducing symptoms of autoimmune disease.3

ISB 830 offers an entirely new mechanism of action to treat autoimmune disease and has the potential to address a range of conditions.4 The treatment may change lives, and the way autoimmune diseases are treated—from now on.

Note: Assets that were previously identified as GBR and GRC are now identified as ISB (for biologics) and ISC (for small molecules), respectively.

  1. Burugu, S., Dancsok, A. R. & Nielsen, T. O. Emerging targets in cancer immunotherapy. Semin Cancer Biol. 52:39-52 (2018).
  2. Glenmark Pharmaceuticals S.A. Glenmark Bispecific Clinical Trials. Available here. NLM identifiers: NCT03983395, NCT02829372, NCT03309111. (Accessed August 12, 2019).
  3. Guttman-Yassky, E. et al. GBR 830, an anti-OX40, improves skin gene signatures and clinical scores in patients with atopic dermatitis. J. Allergy Clin. Immunol. 144:482-493.e7 (2019). Available here.
  4. Glenmark Pharmaceuticals S.A. GBR 830 Clinical Trials. Available here. NLM identifiers: NCT02683928, NCT03568162. (Accessed August 12, 2019).

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